This test option focuses on sporadic cancer risk. At-risk genes are triggered by one another and by the environment (e.g. food, toxins, infections, radiation, products formed during metabolism in obese individuals).
DNA changes that have been shown to have a fairly strong association with cancer risk are helpful in deploying cancer prevention strategies. As research progresses, more evidence will emerge, enabling health professionals to become more specific, adding more DNA targets.
Individuals concerned about breast cancer can already have a targeted approach, as the cancer option can be augmented by a breast cancer risk profile. In obesity-related cancers like colon, ovary and endometrial cancers, the test option can provide those with a family history with a pro-active strategy to eliminate all possible risks as no single abnormal gene has as yet been associated with these conditions.
The test identifies DNA involved in regulating cell processes that protects against injury, including,
• Folate metabolism and high homocystein levels (MTHFR)
• Inflammation and detoxification (ability to protect against free radical injury) (IL6 / TNFa / MnSOD / GSTT / GSTM)
• Estrogen exposure (more relevant in obese persons) that contribute to risk of breast and prostate cancer ) (COMP)
Tests done with regard to breast cancer depend on the risks that are based on family history and other carriers in the family. It will be individualized according to family, ethnic group or population risk.
Read more about the other Health Focus Areas: